In the hospital setting, falls continue to be the top adverse event and injuries from falls are often associated with morbidity and mortality. A considerable body of literature exists on falls prevention and reduction. Successful prevention strategies include identifying patients at highest risk for sustaining serious injury from a fall, multifactorial assessment (estimating danger of falling based on known intrinsic and extrinsic factors), interventions (preventive action to modify and compensate for risk factors), and systematic reporting of falls incidents and their consequences. Many interventions to prevent falls and fall-related injuries require multidisciplinary support for reliable implementation for specific at risk and vulnerable subpopulations, such as the frail elderly and those at risk for injury. All efforts must be made to ensure that patient safety programs are in place across settings of care.