Acute myocardial infarction (AMI) affects 1.1 million people each year, and about 350,000 of them die in the acute phase. Because reliable evidence-based care reduces AMI mortality, IHI’s 100,000 Lives Campaign emphasizes the importance of recommendations in the American Heart Association (AHA)/American College of Cardiology (ACC) guidelines. In this article, the author, from Moses Cone Health Care System in Greensboro, North Carolina, explains the processes that lead to AMI, provides details from the AHA/ACC guidelines, and highlights the ACC’s seven components of care that save lives.