Antman EM, Lau J, Kupelnick B, Mosteller F, Chalmers TC. A comparison of results of meta-analyses of randomized controlled trials and recommendations of clinical experts: Treatments for myocardial infarction. Journal of the American Medical Association. 1992;268(2):240-248.
The authors examine the temporal relationship between accumulating data from randomized control trials of treatments for AMI and the recommendations of clinical experts writing review articles and textbook chapters. Based on the results of a cumulative meta-analysis, they conclude that there are often discrepancies between the most current evidence of effective practice as derived from randomized trials and the recommendations of reviewers.
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