Titrate Anticoagulant Doses

​Laboratory values that indicate coagulation levels in the blood help determine the proper dose of anticoagulant medications. Physicians can direct nurses or pharmacists to titrate or adjust anticoagulant dosages in order to maintain a certain range of those laboratory values. In other words, rather than specifying a particular dose the protocol allows for titration based on — and yielding — actual values (e.g., if aPTT is between 40 and 49, increase dose by 1unit/kg/hour). This method allows for more timely adjustments to dosages and eliminates the need for a physician’s order for every dose adjustment.



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