Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. New England Journal of Medicine. 2000;342(18):1301–1308.
A multi-center, randomized controlled trial comparing a low tidal volume ventilation strategy to traditional ventilation strategies. The authors concluded that in patients with acute lung injury and ARDS, mechanical ventilation with a lower tidal volume resulted in decreased mortality and increased the number of days without ventilator use.
View article abstract