Finney SJ, Zekveld C, Elia A, Evans TW. Glucose control and mortality in critically ill patients. Journal of the American Medical Association. 2003;290(15):2041-2047.
Single-center, prospective, observational study showing that increased insulin administration is positively associated with death in the ICU regardless of the prevailing blood glucose level. Thus, control of glucose levels rather than of absolute levels of exogenous insulin appear to account for the mortality benefit associated with intensive insulin therapy.
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