Adjust Anticoagulants with Thrombolytic and G2b/3A Inhibitors

​When patients receive thrombolytic or G2b/3A inhibitors while they are receiving anticoagulants, they face an increased risk of bleeding. Prescribers must remember to adjust the anticoagulant dosage appropriately to reduce that risk as much as possible. Computerized prescriber order entry systems can provide a reminder of this drug interaction and prompt the prescriber to adjust anticoagulant doses accordingly.



  • Include information about these precautions on any flow sheets, pre-printed orders, or guidelines for anticoagulants.


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