Minimizing potential harm to the patient during an adverse drug event (ADE) requires staff to recognize quickly that an ADE has occurred and to respond rapidly with appropriate interventions. Because some very potent medications are administered only infrequently, staff may not be adept at recognizing an ADE when it occurs or remembering the appropriate interventions to take. ADE drills allow staff to test their skills and practice their response in a safe environment to help improve their reactions when a real ADE occurs. Drills are especially helpful for training those staff who work in areas of the health care organization where ADEs rarely occur.