Pharmacokinetic-pharmacodynamic analysis of drotrecogin alfa (activated) in patients with severe sepsis
Macias WL, Dhainaut JF, Yan BS, et al. Pharmacokinetic-pharmacodynamic analysis of drotrecogin alfa (activated) in patients with severe sepsis. Clinical Pharmacology and Therapeutics. 2002;72:391–402.
This study finds that plasma concentration of drotrecogin alfa (activated) becomes steady soon after infusion begins, and remains so throughout infusion. After infusion is stopped, plasma concentration declines rapidly.
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