Early goal-directed therapy in the treatment of severe sepsis and septic shock
Rivers E, Nguyen B, Havstad S, et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. New England Journal of Medicine. 2001;345(19):1368-1377.
A randomized controlled, single institution trial demonstrating reduction in mortality due to severe sepsis by pursuing early-goal directed therapies.
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