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A meta-analysis of the relative efficacy and toxicity of single daily dosing versus multiple daily dosing of aminoglycosides
Ali MZ, Goetz MB. A meta-analysis of the relative efficacy and toxicity of single daily dosing versus multiple daily dosing of aminoglycosides. Clinical Infectious Diseases. 1997;24:796–809.

This meta-analysis compares once-daily aminoglycoside dosing and standard therapy models, and suggests that once-daily dosing may be preferable. However, this effect may be limited only to those patients who also receive other antimicrobial treatments.



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