This prospective study was performed to examine the complications associated with the use of these catheters in patients receiving long-term total parenteral nutrition (TPN). The two groups were comparable with respect to concomitant infections, treatment with antibiotics, and need for intensive care.  However, after five days of catheterization, there was a marked increase in the number of TLC removed because of skin entry site infections. SLC were more likely to be used for the full duration of TPN administration.