Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation
Kress JP, Pohlman AS, O'Connor MF, Hall JB. Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation. New England Journal of Medicine. 2000;342(20):1471-1477.
Randomized controlled trial in 128 adult patients on mechanical ventilation, randomized to daily interruption of sedation irrespective of clinical state or interruption at the clinician’s discretion. Daily interruption resulted in a marked and highly significant reduction in time on mechanical ventilation.
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