UKPDS 28: A randomized trial of efficacy of early addition of metformin in sulfonylurea-treated type 2 diabetes
United Kingdom Prospective Diabetes Study Group. UKPDS 28: A randomized trial of efficacy of early addition of metformin in sulfonylurea-treated type 2 diabetes. Diabetes Care. 1998;21(1):87-92.
Paradoxical findings that metformin treatment was associated with improved outcomes (compared to those treated with sulfonylurea alone), but that combination metformin/sulfonylurea treatment was associated with worse outcomes.
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